Prevention of
Ovarian Hyperstimulation Syndrome
Journal of
Infertility and reproductive Biology, 2013, Volume 1, Issue 4,
Pages 63-68,
Full Text in PDF (76.6 KB)
Harpreet Kaur
Department of Obstetrics
and Gynecology, Federal Medical Centre Makurdi, Nigeria.
Abstract
Ovarian hyperstimulation syndrome (OHSS) is rare but most
serious complication of ovarian stimulation. Symptoms are mainly
related to increased capillary permeability leading to
extravasation of fluid into extravascular compartment. Disease
pathophysiology is linked to hCG (human chorionic gonadotropin)
which acts through angiogenic molecule vascular endothelial
growth factor (VEGF). There is recent development of interest in
use of dopamine agonist for prevention of OHSS, which act
through blockage of VEGF by preventing phosphorylation of VEGF-2
receptor. Once there is full blown OHSS, treatment is mainly
symptomatic. By careful selection of stimulation protocols &
recognisition of high risk cases at an early stage, early OHSS
can be prevented to a major extent. Use of GnRH antagonist
protocols & GnRH agonist as final trigger leads to marked
reduction in incidence of OHSS without compromising pregnancy
rates. So, prevention has been mainstay of treatment for this
rare but life threatening iatrogenic complication of ovarian
stimulation.
Keywords:
Prevention of OHSS, HCG, VEGF, risk factors.
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Serodynamic of Chlamydia Trachomatis Infection in Women
with in Vitro Fertilization-Embryo Transfer Failures
Journal of
Infertility and reproductive Biology, 2013, Volume 1, Issue 4,
Pages 69-73,
Full Text in PDF
(63.7 KB)
Ibadin KO1, Osemwenkha AP2
1.
Embryologist/ Biomedical Scientist, Human Reproduction Research
Program (HRRP), Department of Obstetrics and Gynecology,
University of Benin, Benin City, Nigeria.
2.
Consultant Obstetrician and Gynaecologist, Human Reproduction
Research Program (HRRP), Department of Obstetrics and
Gynecology, University of Benin, Benin City, Nigeria.
Abstract
The role of Chlamydia trachomatis as
one of the main causes of salpinigitis and infertility in women
has been well acknowledged. A total of 93 sera was screened with
antibodies (IgG) to Chlamydia trachomatis detected in
31(33.3%) suggesting past infections. All sera tested negative
for IgM. Antibodies were found significantly more in patients
with tubal damage 12 (40.0%) while the least antibodies was
found in women with Polycystic ovary syndrome 2(30.0%).
Antibodies to Chlamydia trachomatis were detected
14(45.1%) of the 31 pregnant women and in 26(41.9%) in the 62 of
the nonpregnant women. 47 women had four embryos transferred and
20 became pregnant with 7(10.0%) of these pregnant having
antibodies to Chlamydia trachomatis, while 13(65.0%) were
seropositive for C. trachomatis but not pregnant. A total
of 214 oocytes was recovered with 199(92.9%) satisfactorily
fertilized. There was no difference in fertilization rate of
oocytes in-vitro between those with and those without antibody
to C. trachomatis and between those who became pregnant
and those who did not. Thus, past infected with C.
trachomatis halved the success rate of in-vitro
fertilization; in these patients. The implications of these
findings are relevant to all aspects of infertility particularly
in in-vitro fertilization treatment/procedures.
Keywords:
Chlamydia trachomatis, Serology, IVF-ET failure. |
