J. Infertil. Reprod. Biol.

Volume 3, Issue 2, 2015


Contraceptive practice among married women – A hospital based KAP study


Journal of Infertility and reproductive Biology, 2015, Volume 3, Issue 2, Pages 165-168, | Full Text in PDF (71 KB)


Tabassum Kotagsti


Department of Ilmul Qabalat wa Amraze Niswan (OBG), National Institute of Unani Medicine, Bangalore, India



Women usually desire to have wider birth intervals, hence adopt family planning methods such as oral pills, Intrauterine device, Injections, barrier methods, sterilization etc. which are most commonly practiced in the country. Among these tubectomy is one of the safest permanent operative procedure; complications are rare and occur in less than 1% of all female sterilization operations. Tubectomy gives almost absolute protection against unwanted childbirths as compared with temporary methods. The objective of this study was to find out the choice for the acceptance of tubectomy as permanent method of contraception.  This study was carried out in the Gynaec OPD of NIUM Hospital during the year of 2014-2015. Total 600 women were enrolled in the study and detailed history was obtained regarding the issues and type of family planning method adopted. The collected data was recorded and analyzed. Out of 600 women 344 (57.33%) women adopted temporary methods, whereas 256(42.66%) adopted permanent sterilization (tubectomy). Among temporary methods 137(22.83%) were on OCP, 70 (11.66%) were on IUCD, 62 (10.33%) were on barrier methods and 52 (8.66%) were not used any methods, whereas 256 (42.66%) had tubectomy. Most of the women i.e. 108 (42.18%) had tubectomy operation after two children and least women i.e. 50 (19.53%) had tubectomy operation after five children.  It was observed in Bangalore city that the most of women accepted tubectomy operation especially after two or three children. It may be due to sensitivity of women towards financial status, better education or carrier of their children or better health.


Keywords: Family planning methods, Permanent Sterilization, Tubectomy, Acceptance and Parity


Predictive model for blastocyst stage in in vitro fertilization


Journal of Infertility and reproductive Biology, 2015, Volume 3, Issue 2, Pages 169-173, | Full Text in PDF (91 KB)


Andon Hestiantoro1, Cynthia Agnes Susanto1, Eliza Mansyur1, Putri Deva Karimah2


1. Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia

2. Yasmin Reproductive and Infertility Clinic – Dr. Cipto Mangunkusumo National Hospital Kencana, Jakarta 10430, Indonesia



This study aims to determine predictive model for blastocyst stage development in In Vitro Fertilization (IVF). We retrieved embryos upon day five in January 2012 to October 2012. Categorical variables were compared using chi-square test and continues variables were analyzed using independent t-test, while p<0.05 was considered statistically significant. To identify the relationship between statistically significant variables with occurrence of blastocyst, multivariate logistic regression analysis was done. We identified 302 embryos from 37 subjects whom at least one embryo achieved blastocyst stage. Among which, we found 154 blastocysts (51%) and 148 embryos (49%) which did not achieve blastocyst stage. Two variables were statistically significant in influencing the formation of blastocyst, which are symmetrical pro nucleotide morphology with OR 4.08 (95% CI 2.30-7.25, p<0.001) and number of cells in day-2 with OR 2.20 (95%CI 1.33-3.64, p=0.001). Logistic regression analysis revealed that symmetrical pro nucleotide morphology and four cells number gave good chance of blastocyst prediction. Predictive model was Z = -1.236 + 1.203 (pro nucleotide score) + 0.732 (four cells score). This study reveals the symmetrical pro nucleotide morphology and four cells score as predictive model for blastocyst stage in IVF.


Keywords: Blastocyst stage, Embryo, IVF, Morphology


Psychosocial wellbeing and coping strategies of infertile women seeking infertility treatment


Journal of Infertility and reproductive Biology, 2015, Volume 3, Issue 2, Pages 174-178, | Full Text in PDF (66 KB)


D’Souza Vinitha1, Noronha Judith Angelita2, Kamath Shobha3


1. Manipal College of Nursing, Manipal University, Manipal, India

2. Department of Obstetrics and Gynecological Nursing, Manipal College of Nursing, Manipal University, Manipal, India

3. Department of Obstetrics and Gynecological Nursing, Manipal College of Nursing, Manipal University, Manipal, India



Infertility refers to the inability of a couple to produce a child even after a year of repeated unprotected intercourse. It has great impact on people’s lives and their psyche. The objectives of this study were to assess the psychosocial wellbeing and coping strategies, to examine its relationship and to find the association with selected demographic variables. A cross sectional survey (n=180) design was used to assess the psychosocial wellbeing and coping strategies of infertile women (aged 20-40 years) seeking infertility treatment in selected infertility clinics of Udupi District Karnataka. Study results showed that majority of the study population (146, 81.1%) had moderate level of psychosocial wellbeing and coped with seeking social support (65.7%). There was a difference in mean scores and standard deviation in sub areas of psychological wellbeing (42.5±5.95), social wellbeing (45.37±5.7). Women with good psychosocial wellbeing used less coping strategies(r = -0.2, p<0.01). There was a significant association between psychosocial wellbeing and educational status of infertile women (p=0.001) and coping strategies with type of the family (p=0.01). Study findings concluded that infertile women do have disturbed psychosocial wellbeing. So counseling sessions is needed to improve their psychosocial wellbeing and to get focus on their treatment.


Keywords: Infertile women, Infertility, Infertility treatment, Psychosocial wellbeing, Coping strategies


Evaluation of polycystic ovary syndrome patients treated for OHSS


Journal of Infertility and reproductive Biology, 2015, Volume 3, Issue 2, Pages 179-183, | Full Text in PDF (86 KB)


Şafak Hatirnaz1, Servet Gençdal2, Melahat Atasever3, Emre Ekmekçi4, Murat Bakacak5, Sefa Kelekçi4


1. Trabzon Clinart IVF Center Trabzon,Turkey

2. İzmir Atatürk Research and Education Hospital, Gynecology and Obstetric Department, İzmir, Turkey

3. Giresun University Medicine Faculty, Gynecologyand Obstetric Department, Giresun , Turkey

4. İzmir Katip Çelebi University Medicine Faculty, Gynecology and Obstetric Department, İzmir, Turkey

5.  Kahramanmaraş Sütçü  İmam  University  Medicine  Faculty,  Gynecology  and  Obstetric  Department, Kahramanmaraş, Turkey



We aimed to present the management, hospitilizationtime, pregnancy rates and complications of our polycystic ovary  syndrome  (PCOS)  patients  that  we  treated  for  OHSS  in  our  clinic.  Therefore  this  study  is  designed  by analyzing of retrospectively collected data of 31 PCOS patients who were treated for OHSS. Diagnosis of PCOS is based on Rotterdam criteria that is published in 2003 and OHSS diagnosis is based on classification that is formed by Golan et al. GnRH (Ovitrelle® 250 mcg subcutan) is used for final maturation of oocytes. Same protocol is used for all patients at hospitalization. Results showed that GnRH agonist protocol is used for 23 patients and GnRH antagonist protocol is used for 8 patients. 8 patients (%25) were mild, 19 patients (%61) were moderate and 4 patients (%1,2) were severe OHSS. 13 patients (%42) were early onset OHSS and 18 patients (%58) were late onset OHSS.  Mean oocyte counting was 21±6,3. Total freezing is used for 13 patients (%42) pregnancy is resulted for 13 patients. Mean total transvaginal aspiration liquid volume was 4800cc ±1786 cc in hospitalization. Abortion is not induced for any patient. Require for intensive care or mortality isnot resulted at any patient. Mean hospitalization time was 7±2,6 days. We concluded that altough a lot of strategiesare performed recently to prevent OHSS, it is still a problem. Early diagnosis and prevention of severe OHSS is very important to prevent fatal complications.


Keywords: OHSS, PCOS, Dopamin agonist, Cabergoline, Assisted Reproductive Techniques



Y chromosome microdeletion analysis reveals predominant AZFc deletions and absence of germline specific deletions among idiopathic infertile males in a south Indian population


Journal of Infertility and reproductive Biology, 2015, Volume 3, Issue 2, Pages 184-191, | Full Text in PDF (188 KB)


Venugopal Satidevi Vineeth1, Sreenivasa Gopalappa1, Suttur Srikantanaik Malini1


1. Molecular Reproductive and Human Genetics Lab, Department of Studies in  Zoology, University of

Mysore, Manasagangothri, Mysore, Karnataka, India



Y chromosome microdeletions in any of the three azoospermia factor loci AZFa, AZFb and AZFc affects spermatogenesis causing irreversible male infertility. In the present study Yq deletion frequency, deletion types and associated infertile conditions were analyzed among240 idiopathic infertile males (102 severe oligospermic and 138 azoospermic) and 100 fertile control individuals ofa south Indian population previously not assessed.Polymerase chain reaction analysis for Yq microdeletions was performed using genomic DNA employing eight sequencetagged sites markers. Germ line specific Yq deletions werealso assessed among 86 severe oligospermic males using sperm DNA. Apart from these, sperm sex chromosomal aneuploidies were analyzed among 20 severe oligospermic and oligoasthenospermic infertile individuals through fluorescence in situhybridization technique. Among 240 infertile individuals assessed 13 (5.4%) men were identified to harbour interstitial Y chromosome microdeletions. AZFc region deletions involving DAZgene cluster was observed to be predominant (69.2%) followed by AZFb deletions (15.4%) and AZFbc deletions (15.4%). Statistically significant difference was observed in the Yq deletion frequency between the severe oligospermic and azoospermic individuals (χ2 = 4.13, df =1,p=0.042). Germ line specific deletions were observed to be completely lacking among severe oligospermic individuals. Insignificant difference was observed in sperm sex chromosomal aneuploidy rates between the oligospermic and control individuals. Influence of genetic and environmental factors, sampling and methodological differences can be attributed to the differences in Yq deletion frequency observed within Indian populations. Germ cell specific Yq deletions and sperm sex chromosome aneuploidy may not be always associated with severe infertility.


Keywords: Azoospermia, Oligospermia, Azoospermia factor regions, Sequence tagged sites, Microdeletions


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