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J. Infertil. Reprod. Biol.

Volume 5, Issue 2, 2017

 

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The Role of Nanotechnology-Based Photodynamic Therapy in the Treatment of Ovarian Cancer

 

Journal of Infertility and reproductive Biology, 2020, Volume 8, Issue 3, Pages 5-11, | Full Text in PDF | Full Text in HTML

 

Mitra Taghipour1, Marzieh Khodadadi2, Hamid Reza Ghaderi Jafarbeigloo3, Faezeh Jadidi4*, Mahmoud Mehdinejad5*

 

1Department of Biotechnology, Faculty of Agriculture and Natural Resourses, Imam Khomeini International University, Qazvin, Iran

2Department of Chemistry, Faculty of Chemistry, Payame Noor University (PNU), P.O. Box, 19395-3697, Tehran, Iran

3Department of Basic Science, Payame Noor University, Iran

4Student Resesrch committee, Zarand School of Nursing, Kerman University of Medical Sciences, Kerman, Iran

5Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shahroud University of Medical Sciences, Shahroud, Iran

 

 

Abstract

Ovarian cancer is one of the most dangerous and deadly cancers in women. This cancer progresses very quickly and metastasizes to the peritoneal cavity and pelvis. It is called silent death because 75% of patients who refer to hospitals are diagnosed at advanced stages of the disease. Transvaginal ultrasonography, Cancer antigen (CA125, Doppler imaging, Human kallikrein 10 (hK10), lysophosphatidic acid (LPA), computerized tomography scans, cytology and / or biopsy are used to diagnose ovarian cancer. Surgery and chemotherapy are also among common treatments used for the treatment of ovarian cancer. However, these traditional therapies have a variety of side effects, including nausea, vomiting, peripheral neuropathy, neurotoxicity. Nanotechnology with its unique features can overcome these limitations and problems. Nanoparticles can use modern therapies, such as nanotechnology-based photodynamic therapy, nanotechnology-based gene therapy, nanotechnology-based radiotherapy and radiofrequency therapy, and nanotechnology-based cancer theranostic that can helps in the treatment of cancer. Nanotechnology-based photodynamic therapy is considered one of the most effective, safe, and novel methods in cancer treatment. The use of nanoparticles as photosensitizers can overcome many of the limitations of traditional therapies. Nanoparticles can be targeted to specific sites, controllable, in some cases, used in a way to produce ROS. The use of nanotechnology can attenuate toxicity in target sites and greatly reduce injuries to normal cells.

 

Keywords: Ovarian cancer; Nanotechnology; Photodynamic therapy, Nanoparticles, Photosensitizers

 

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