J. Infertil. Reprod. Biol.

Volume 6, Issue 1, 2018


Mitochondrial Fatty Acid Transport System and its Relevance to Ovarian Function


Journal of Infertility and Reproductive Biology, 2018, Volume 6, Issue 1, Pages 1-3,|Full Text in PDF and HTML (267 KB)


Mona Sharma


 Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi-110029, India



Mitochondrial fatty acid oxidation is integral to folliculogenesis and oocyte maturation. Mitochondrial fatty acid transport system includes molecules such as 3-hydroxy-4-trimethylamino butyrate or carnitine, organic cation transporter novel 2 (OCTN2), carnitine palmitoyl transferase (CPT1), CPT2, and carnitine-acylcarnitine translocase (CACT). These are essential molecules that play an important role in the transport of activated long chain fatty acids from cytosol to the mitochondrial matrix where these subsequently undergo beta-oxidation. It has been well established that fatty acid metabolism is vital for follicles and oocyte growth. This review highlights the possible role of mitochondrial fatty transport acid system in ovarian function.


Keywords: Oocytes, Carnitine, Mitochondria, Fatty acids



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