J. Infertil. Reprod. Biol.

Volume 6, Issue 3, 2018


Histopathology and Biochemical Analysis of Pentazocine Effect on Ovary, Uterus, Adrenal Gland and Thyroid Gland of Female Albino Rats


Journal of Infertility and reproductive Biology, 2018, Volume 6, Issue 3, Pages 9-15, | Full Text in PDF and HTML (704 KB)|

Sneha R. Banagar1, Ravikumar J. Banagar1, Sharangouda J. Patil2*


1 Department of Zoology, L. V. D. College, Raichur-584103, Karnataka, India

2 Department of Life Sciences, School of Sciences, Garden City University, Bangalore, Karnataka, India



Many drugs are known to interfere with the functions of CNS including hypothalamus there by modify the activity of hypophysis and gonads. Due to that many functions alters by them, such as the secretion and release of pituitary follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) are directly dependent on gonadotropic releasing hormones (GnRH). The effect of pentazocine on endocrine organs like ovary, uterus, thyroid and adrenal glands, there estrous cycle, gravimetrical changes, histological changes and biochemical changes has been evaluated. Three groups of healthy adult female albino rats having six rats in each group were taken. The rats of groups II and III were administered pentazocine at the dose level 0.5mg and 1.0mg/100g body weight respectively intraperitoneally/daily for 30 days. However, the rats of group I (Control) were given saline alone.After the experimental periods, the rats were sacrificed and the histological study of ovary and uteri, thyroid and adrenal gland were performed. Body weight, estrous cycle, ovarian histometric elements of the follicles were non significant and histometrical changes of uterine parameters like diameter, thickness of myometrium and endometrium and surface epithelial cell height increased significantly. Biochemical changes of endocrine glands are parallel to the gravimetrical changes, the protein and glycogen contentsincreased significantly and reduced cholesterol content significantly with respective administration of both the dose level of pentazocine. Also, the gravimetric analysis of thyroid and adrenal gland increased significantly due to pentazocine administration. The study indicates that pentazocine has slightly stimulatory action on endocrine activities related to female reproduction.



Keywords: Pentazocine, Endocrine glands, Estrous cycle, Ovary, Endometrium



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