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J. Infertil. Reprod. Biol.

Volume 8, Issue 2, 2020

 

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Spermatogenic Efficacy of Pausinystalia yohimbe (K. Schum.) Pierre ex Beille Roots in Male Rats

 

Journal of Infertility and reproductive Biology, 2020, Volume 8, Issue 1, Pages 9-17, | Full Text in PDF | Full Text in HTML

 

Adekunle O. Ojatula*

 Phytomedicine Research Centre, Botany Unit, Department of Biological Sciences, Faculty of Science, Ondo State University of Science and Technology,   Okitipupa, Nigeria

 

Abstract

Background: The roots of Pausinystalia yohimbe have been traditionally acclaimed as aphrodisiac. In the present study, methanol extract of the root was evaluated for its effect on sexual orientation behaviour and spermatogenesis in albino Wistar rats.

Methods: Forty five (45) male albino rats were randomly divided into five groups of nine rats each. Rats in group I (control) were administered 1 mL/kg body weight distilled water (vehicle), group II received 5 mg/kg body weight sildenafil citrate (Viagra), while those in groups III, IV, and V were given 25, 50, and 100 mg/kg body weight, respectively, of methanol extract of Pausinystalia yohimbe root in the same volume. Female albino rats were made receptive by hormonal treatment. Sexual orientation behaviour parameters were monitored on days 1, 7 and 14 by pairing with receptive females. A change in sexual orientation behaviuor was assessed by orientation towards female, towards environment and towards self, while spermatogenic activity was evaluated on day 14.

Results: Administration of the extract had pronounced effect on sexual orientation behaviour of male towards the female rats on days 7 and 14. Males treated with the extract displayed more frequent and vigorous anogenital sniffing and mounting as compared to untreated animals. Libido was also at increase in extract treated male rats. The extract had stimulated the spermatogenetic activity and accessory reproductive organs performance in albino rats. The increased spermatogenesis in extract treated groups was confirmed by change in histoarchitecture as evidenced by increase in number of spermatogenic elements and parameters.

Conclusion: P. yohimbe exhibited remarkable increase in sexual orientation, libido and spermatogenic activity which are some of the indices that determine the ability of a male to produce viable spermatozoa. These findings support the folk use of this plant as an aphrodisiac.

 

Keywords: Aphrodisiac, Herbal drugs, Pausinystalia yohimbe, Sexual orientation, Spermatogenesis

 

 

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COVID 19 Pandemic, Mechanism of Pathogenesis, Preventions and Possible Cures to Save Humanity: A Study

Journal of Infertility and reproductive Biology, 2020, Volume 8, Issue 1, Pages 18-21, | Full Text in PDF | Full Text in HTML

Samanwita Banerjee, Jainendra Gupta, Anil Kanaujia

 

Ayurvet Research Foundation, Chidana, Haryana, India

 

 

Abstract

The name "coronavirus" is derived from Latin corona, meaning "crown" or "wreath due to the characteristic appearance of virions , which have a fringe of large, bulbous surface projections creating an image reminiscent of a crown or of a solar coronaHuman coronaviruses were discovered in the 1960s. The third novel coronavirus to emerge in this century is called SARS-CoV-2. It caused coronavirus disease 2019 (COVID-19), which emerged from China in December 2019 and was declared a global pandemic by the World Health Organization on March 11, 2020. The virus enters into the host body through the mouth, nose and eye.  From there, the virus makes its way down into the air sacs inside the lungs, known as alveoli. Once in the alveoli, the envelope spike glycoprotein present in the virus binds to its cellular receptor, angiotensin-converting enzyme 2 (ACE2) for SARS-CoV-2. There are two commonly used nucleic acid detection technologies forSARS-CoV-2 are real-time quantitative polymerase chain reaction (RT-qPCR) and high-throughput sequencing. With no sure shot vaccine/ drug in sight till late 2021, medical practioners are using existing therapies and repurposing drugs to save lives. Prevention is the only way to stay safe and healthy. Immunity plays an important role in this disease, so it important have nutritious and healthy food to boost the immunity.

 

Keywords: COVID 19, SARS-CoV-2, Vaccine, ACE2, RT-q PCR.

 

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