Moreover, treatment options are lacking in POF. Therefore,
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search on early diagnostic markers and treatment options is
utmost important. The future research should focus creating
POF disease models using factors regulating mitochondrial
fatty acid transport system. Identification of novel gene
mutations in SLC22A5, TMLHE, CPT1A, CPT2, CACT will
help in structuring biomarker gene panel for early identification
of idiopathic POF. Validation studies in larger number of
cohorts can mark the gene panel as biomarker of metabolic
etiology of POF. This will help in identifying POF at an earlier
stage where fertility preservation is possible. Designing
supplement options based on regulating molecules of fatty acid
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in ovarian disorders such as POF. Fatty acid transport system in
mitochondria is integral for efficient beta oxidation. Therefore,
studying their association in ovarian functions will be a potential
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Authors are aware of, and comply with, best practice in
publication ethics specifically with regard to authorship
avoidance of guest authorship), dual submission, and
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manipulation of figures, competing interests and compliance with
policies on research ethics. Authors adhere to publication
requirements that submitted work is original and has not been
published elsewhere in any language.
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The authors declare that there is no conflict of interest that
would prejudice the impartiality of this scientific work.
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