of it can cause infertility in females (31). Abnormality of
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LDL-c had not been consistently reported in some cases of
infertility. Even those with normal LDL-c levels had shown
increase VLDL-c relative to the control group (32). A
significantly higher index of atherogenicity was observed
among infertile women when compared with the fertile
group. This implies that infertile women have a higher risk
of developing cardiovascular diseases than the fertile group.
This is particularly important because Black Africans are
known to have lower lipid levels than Caucasians (33).
Therefore, the use of lipid levels to diagnose cardiovascular
diseases in Africans may be misleading. Glew et al. (17)
reported that they were able to differentiate patients with
stroke from normal individuals via the use of cardiac risk
ratios. The need to identify prospective women seeking
intervention via assisted reproductive technology who are at
risk of CVD cannot be overemphasized.
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Plasma triglyceride, total cholesterol, LDL-c, and
indices of atherogenicity (except HDL-c/LDL-c ratio) were
significantly higher while HDL-c was significantly lower
among infertile women seeking conception via assisted
reproduction. It is suggested that this group of women may
benefit from periodic lipid profiles and indices of
atherogenicity determination for fertility potential and/or
CVD risk assessments.
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The contribution of Prof. O. Giwa-Osagie and his team
during this study is appreciated.
Conflicts of interest
The authors declare that there is no conflicts of interest.
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